I’m currently playing through fallout 4 with mods. the hardest part was figuring out how to install MO2 and make it recognize Fo4 on steam, I followed the guide here: https://github.com/rockerbacon/modorganizer2-linux-installer
after that, installing mods are the same as on windows.
it seems like it does but I didn’t tested, there is a part of the install script that adds a handler for nexus links but I opted to not install that part.